Safety and efficacy of pitolisant on cataplexy in patients with narcolepsy: a randomised, double-blind, placebo-controlled trial.
Identifieur interne : 000400 ( Main/Exploration ); précédent : 000399; suivant : 000401Safety and efficacy of pitolisant on cataplexy in patients with narcolepsy: a randomised, double-blind, placebo-controlled trial.
Auteurs : Zoltan Szakacs [Hongrie] ; Yves Dauvilliers [France] ; Vladimir Mikhaylov [Russie] ; Irina Poverennova [Russie] ; Sergei Krylov ; Slavko Jankovic [Serbie] ; Karel Sonka [République tchèque] ; Philippe Lehert [Australie] ; Isabelle Lecomte [France] ; Jeanne-Marie Lecomte [France] ; Jean-Charles Schwartz [France]Source :
- The Lancet. Neurology [ 1474-4465 ] ; 2017.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Antihistaminiques des récepteurs H3 (usage thérapeutique), Bases de données bibliographiques (), Cataplexie (traitement médicamenteux), Cataplexie (étiologie), Femelle, Humains, Indice de gravité médicale, Jeune adulte, Mâle, Méthode en double aveugle, Narcolepsie (), Pipéridines (usage thérapeutique), Résultat thérapeutique, Sujet âgé, Études de suivi, Études rétrospectives.
- MESH :
- traitement médicamenteux : Cataplexie.
- usage thérapeutique : Antihistaminiques des récepteurs H3, Pipéridines.
- étiologie : Cataplexie.
- Adolescent, Adulte, Adulte d'âge moyen, Bases de données bibliographiques, Femelle, Humains, Indice de gravité médicale, Jeune adulte, Mâle, Méthode en double aveugle, Narcolepsie, Résultat thérapeutique, Sujet âgé, Études de suivi, Études rétrospectives.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Cataplexy (drug therapy), Cataplexy (etiology), Databases, Bibliographic (statistics & numerical data), Double-Blind Method, Female, Follow-Up Studies, Histamine H3 Antagonists (therapeutic use), Humans, Male, Middle Aged, Narcolepsy (complications), Piperidines (therapeutic use), Retrospective Studies, Severity of Illness Index, Treatment Outcome, Young Adult.
- MESH :
- chemical , therapeutic use : Histamine H3 Antagonists, Piperidines.
- complications : Narcolepsy.
- drug therapy : Cataplexy.
- etiology : Cataplexy.
- statistics & numerical data : Databases, Bibliographic.
- Adolescent, Adult, Aged, Double-Blind Method, Female, Follow-Up Studies, Humans, Male, Middle Aged, Retrospective Studies, Severity of Illness Index, Treatment Outcome, Young Adult.
Abstract
Histaminergic neurons are crucial to maintain wakefulness, but their role in cataplexy is unknown. We assessed the safety and efficacy of pitolisant, a histamine H3 receptor inverse agonist, for treatment of cataplexy in patients with narcolepsy.
DOI: 10.1016/S1474-4422(16)30333-7
PubMed: 28129985
Affiliations:
- Australie, France, Hongrie, Russie, République tchèque, Serbie
- Bohême centrale, Hongrie centrale, Île-de-France
- Budapest, Paris, Prague
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Le document en format XML
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Schwartz</name><affiliation wicri:level="3"><nlm:affiliation>Bioprojet Pharma, Paris, France. Electronic address: jc.schwartz@bioprojet.com.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Bioprojet Pharma, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">The Lancet. Neurology</title><idno type="eISSN">1474-4465</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Cataplexy (drug therapy)</term><term>Cataplexy (etiology)</term><term>Databases, Bibliographic (statistics & numerical data)</term><term>Double-Blind Method</term><term>Female</term><term>Follow-Up Studies</term><term>Histamine H3 Antagonists (therapeutic use)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Narcolepsy (complications)</term><term>Piperidines (therapeutic use)</term><term>Retrospective Studies</term><term>Severity of Illness Index</term><term>Treatment Outcome</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Antihistaminiques des récepteurs H3 (usage thérapeutique)</term><term>Bases de données bibliographiques ()</term><term>Cataplexie (traitement médicamenteux)</term><term>Cataplexie (étiologie)</term><term>Femelle</term><term>Humains</term><term>Indice de gravité médicale</term><term>Jeune adulte</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Narcolepsie ()</term><term>Pipéridines (usage thérapeutique)</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Études de suivi</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Histamine H3 Antagonists</term><term>Piperidines</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Narcolepsy</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Cataplexy</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cataplexy</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Databases, Bibliographic</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Cataplexie</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antihistaminiques des récepteurs H3</term><term>Pipéridines</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Cataplexie</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Double-Blind Method</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Retrospective Studies</term><term>Severity of Illness Index</term><term>Treatment Outcome</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Bases de données bibliographiques</term><term>Femelle</term><term>Humains</term><term>Indice de gravité médicale</term><term>Jeune adulte</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Narcolepsie</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Études de suivi</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Histaminergic neurons are crucial to maintain wakefulness, but their role in cataplexy is unknown. We assessed the safety and efficacy of pitolisant, a histamine H3 receptor inverse agonist, for treatment of cataplexy in patients with narcolepsy.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Hongrie</li><li>Russie</li><li>République tchèque</li><li>Serbie</li></country><region><li>Bohême centrale</li><li>Hongrie centrale</li><li>Île-de-France</li></region><settlement><li>Budapest</li><li>Paris</li><li>Prague</li></settlement></list><tree><noCountry><name sortKey="Krylov, Sergei" sort="Krylov, Sergei" uniqKey="Krylov S" first="Sergei" last="Krylov">Sergei Krylov</name></noCountry><country name="Hongrie"><region name="Hongrie centrale"><name sortKey="Szakacs, Zoltan" sort="Szakacs, Zoltan" uniqKey="Szakacs Z" first="Zoltan" last="Szakacs">Zoltan Szakacs</name></region></country><country name="France"><noRegion><name sortKey="Dauvilliers, Yves" sort="Dauvilliers, Yves" uniqKey="Dauvilliers Y" first="Yves" last="Dauvilliers">Yves Dauvilliers</name></noRegion><name sortKey="Lecomte, Isabelle" sort="Lecomte, Isabelle" uniqKey="Lecomte I" first="Isabelle" last="Lecomte">Isabelle Lecomte</name><name sortKey="Lecomte, Jeanne Marie" sort="Lecomte, Jeanne Marie" uniqKey="Lecomte J" first="Jeanne-Marie" last="Lecomte">Jeanne-Marie Lecomte</name><name sortKey="Schwartz, Jean Charles" sort="Schwartz, Jean Charles" uniqKey="Schwartz J" first="Jean-Charles" last="Schwartz">Jean-Charles Schwartz</name></country><country name="Russie"><noRegion><name sortKey="Mikhaylov, Vladimir" sort="Mikhaylov, Vladimir" uniqKey="Mikhaylov V" first="Vladimir" last="Mikhaylov">Vladimir Mikhaylov</name></noRegion><name sortKey="Poverennova, Irina" sort="Poverennova, Irina" uniqKey="Poverennova I" first="Irina" last="Poverennova">Irina Poverennova</name></country><country name="Serbie"><noRegion><name sortKey="Jankovic, Slavko" sort="Jankovic, Slavko" uniqKey="Jankovic S" first="Slavko" last="Jankovic">Slavko Jankovic</name></noRegion></country><country name="République tchèque"><region name="Bohême centrale"><name sortKey="Sonka, Karel" sort="Sonka, Karel" uniqKey="Sonka K" first="Karel" last="Sonka">Karel Sonka</name></region></country><country name="Australie"><noRegion><name sortKey="Lehert, Philippe" sort="Lehert, Philippe" uniqKey="Lehert P" first="Philippe" last="Lehert">Philippe Lehert</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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